10. The Plague Of Athens


Greece experienced a pandemic known as the Plague of Athens in 430 BC, at the height of the Peloponnesian War. Typhoid, smallpox, and measles have all been suggested as possible causes of the plague, but it is most frequently believed to have been a form of the bubonic plague. Historians have been unable to agree on precisely what the plague was. The disease first appeared when Athenians sought refuge behind the city-state’s walls from the advancing Spartan troops. Inevitably, the claustrophobic living conditions served as a breeding ground for the epidemic, which is thought to have killed one in three citizens of the city-state, including its ruler, Pericles.

9. Malaria


Malaria remains one of the most deadly pandemics in the world, infecting up to 500 million people annually despite being largely contained to the tropics. The illness, which is brought on by a parasite found in some insects, is drug-resistant, and a reliable vaccine hasn’t yet been created. It is well known that malaria and its effects have been a significant influence throughout history. Many believe that malaria played a role in the decline and ultimate fall of the Roman Empire because there were over a million cases of the illness during the American Civil War alone.

8. The Antonine Plague

Despite bing primarily restricted to the tropics, malaria continues to be one of the deadliest pandemics in the world, infecting up to 500 million people annually. Drug-resistant and without a reliable vaccine, the disease is caused by a parasite that lives in some insects. It is common knowledge that malaria and its consequences have had a big historical impact. Because there were over a million cases of the illness during the American Civil War alone, many people think that malaria played a part in the decline and eventual collapse of the Roman Empire.


The Antonine Plague, which ravaged the Roman Empire from 165 to 180 AD, is now thought to have been a measles or smallpox epidemic. The illness, also known as the Plague of Galen, is thought to have been brought to Rome by soldiers who had just returned from a fight. According to estimates, the Antonine Plague killed up to 5 million people at its height, or a quarter of all those it affected, including two of Rome’s emperors. A comparable illness appeared in 251 AD, and many people think it was the Plague of Antonine resurfacing. This outbreak was referred to as the Plague of Cyprian, and at its worst, the illness is reported to have been fatal.

7. Typhus


Typhus, which is known for spreading rapidly in confined spaces and unhygienic conditions, is blamed for millions of fatalities in just the 20th century. Due to how it frequently appears to flare up on the front lines during times of conflict, the illness is also known as “camp sickness.” A typhus pandemic is credited with killing 8 million Germans during the 30-year war, and it is well known that the illness was a major cause of mortality in Nazi concentration camps. The French force was nearly wiped out by typhus during Napoleon’s invasion of Russia, which is perhaps its most illustrious claim to fame. Up to 400,000 of his soldiers may have perished from the illness, which is a significant number more than were slain in battle.

6. The 7 Cholera Pandemics


Between 1816 and the beginning of the 1960s, millions of people were killed by cholera, one of the historically most deadly diseases, and its alleged “seven pandemics.” The illness, which is typically spread through contaminated food or water, first appeared in India, where it is estimated that up to 40 million people died there between 1817 and 1860. It quickly expanded to Western Europe and the US, where it killed over 100,000 people by the middle of the 1800s. Since then, cholera has occasionally broken out again, but medical advancements have made it a much less deadly illness. Cholera is now only fatal in the rarest of circumstances, whereas it once had a mortality rate of 50% or higher when properly managed.

5. The Third Pandemic

Following the Black Death and the Plague of Justinian, the Third Pandemic was the third significant epidemic of the bubonic plague. It began in China in the 1850s and ultimately spread to all six continents with populations before slowing down in the 1950s. Although it is now regarded as inactive, a few isolated cases of the disease were found in the western United States as recently as 1995. Despite contemporary medical advancements, the Third Pandemic still claimed up to 12 million lives in China and India.

4. Smallpox


Smallpox devastated the Americas when it was first brought to the continent by European settlers in the 15th century, but it has since been effectively eradicated. Smallpox was the most dangerous illness that was introduced to the new world, and it is thought to have killed millions of native Americans and people in Central America. The Spanish eventually conquered the Aztec and Incan civilizations due in large part to smallpox, which wiped out both societies. Back in Europe, where it is believed to have killed 60 million people in just the 18th century, the illness was just as dangerous.

3. The Plague of Justinian


The Plague of Justinian was an especially virulent illness that erupted in the Byzantine Empire around 541 AD. It is generally regarded as one of the first pandemics in recorded history. Although precise figures are unknown, the plague is thought to have killed at least one in four people in the eastern Mediterranean area, and it is estimated to have killed 100 million people worldwide—5,000 per day at its height. The Plague of Justinian had far-reaching political effects in addition to its shocking mortality rate because its devastation prevented the Byzantine Empire from expanding into Italy, which profoundly altered the path of European history.

2. The Spanish Flu

The Spanish Flu of 1918, which followed World War I’s destruction, is regarded by many as one of the worst pandemics in history. It was a global occurrence that is thought to have affected one-third of humanity as a whole and resulted in up to 100 million deaths. The virus, which was later determined to be a strain of H1N1, would often arrive in communities in waves before swiftly leaving. Governments tried to minimise the flu’s severity out of fear of a major uproar, and because of censorship during the war, its extensive effects weren’t completely understood for several years. Only Spain, a neutral nation during World War I, permitted in-depth press coverage of the pandemic, which is

1. The Bubonic Plague (The Black Death)

The Black Death, a severe epidemic of bubonic plague that wracked Europe for the majority of the 1300s, is arguably the most well-known pandemic in history. According to recent study, 45–50% of the population of Europe was wiped out during the plague, which was characterised by the development of oozing and bleeding sores on the body and a high fever. The plague is thought to have killed 75–200 million people in the 14th century alone. The last significant outbreak of the plague occurred in London in the 1600s, but it would continue to pose a danger for the next 100 years, periodically reappearing and killing thousands.

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